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This functional loss may stem from age-related phagocytic exhaustion and the direct toxicity of iron-rich A and tau aggregates toward microglia (155) Furthermore, prior cell culture studies confirm that amyloid exposure accelerates microglial senescence (156)

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Compared to the combination of sertraline with artemether, the combination of sertraline and chloroquine showed a stronger synergy with less toxicity to PHGDH wild type cells